[a. F. vacuole (Dujardin), f. L. vacu-us empty.]

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  1.  A small cavity or vesicle in organic tissue or protoplasm, freq. containing some fluid.

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  a.  Zool. and Anat.  1853.  Ray Soc. Bot. & Physiol. Mem., 534. All these properties had already been observed by Dujardin;… the aqueous spaces or hollows he named ‘Vacuoles,’ regarding them as the most characteristic feature of the substance.

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1859.  Huxley, Oceanic Hydrozoa, 10. The structure of the villi and vacuoles in Athorybia.

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1897.  Allbutt’s Syst. Med., II. 224. Into the vacuoles or loculi of this net-work the serum exudes.

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  b.  Bot.  1875.  Darwin, Insectiv. Plants, xv. 351. Two or three vacuoles or small spheres appeared within some of the larger globules.

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1885.  Goodale, Physiol. Bot. (1892), 280. In numerous succulents the vacuoles of the assimilating cells frequently contain a thin mucus.

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  attrib.  1882.  Vines, trans. Sachs’ Bot., 585. The centre of the sac is filled in the unripe seed with a clear vacuole-fluid.

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  2.  An empty or open space (in a comet).

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1881.  Science, II. 317. In this envelope was a curious oval vacuole, behind the nucleus, but on the preceding side of the axis of the tail.

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