Physiol. A layer of a light buff color forming the upper part of the clot of coagulated blood under certain conditions.

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1800.  Med. & Phys. Jrnl., III. 454. There being on the blood a slight buffy coat.

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1845.  Todd & Bowman, Phys. Anat., 37. A yellowish white layer … called the buffy coat or inflammatory crust.

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1874.  Jones & Siev., Pathol. Anat., 22. This layer is fibrine separated from the red corpuscles, and is commonly termed the ‘buffy coat.’

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